The quality of clinical trials is markedly influenced by the competency of clinical research nurses. An employability curriculum must provide be rooted in the evidence-based practices. This study identified the common duties and tasks of research nurses working on human trials in Taiwan. A human trial is experimental research that assess the effects, both positive and negative, of, say, a new medical technology, new drug, new medical procedure, or the bioavailability and bioequivalence of generic drugs. This study had two phases. The first phase described and identified the common duties and tasks of clinical research nurses in four areas of a human trial: new medical technology; new drug; new medical procedure; and the bioavailability and bioequivalence of generic drugs. In-depth interviews with each area 2–4 nurses in each area were conducted to determine the importance and occurrence of theses duties. Eleven valid transcripts were obtained. According to cognitive task analysis and principles of flow chart design, data for the four areas were analyzed, : (a) common duties (pre-study , study period, study close-out, and quality assurance); (b) tasks in the four areas (13 new medicines, 12 new medical technologies, 12 new medical procedures, 12 bioavailability and bioequivalence studies of generic drugs); according to literature review results, (c) the named and defined tasks were sorted and characterized; and (d) a checklist was developed of for each task. The second phase identified the common tasks of in the four areas, as the basis of for modular courses for the further development of skills. In total, 2 or 3 senior clinical research nurses from each area participated in group meetings. The four groups confirmed the accuracy of each task’s name, and definition, and procedural description. Finally, there are 14 common tasks in the four areas of human trails were identified.